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Malignant Gastrointestinal Stromal Tumor

MedGen UID:
465816
•Concept ID:
C3179349
•
Neoplastic Process
Synonym: Gastrointestinal Stromal Sarcoma
SNOMED CT: Gastrointestinal stromal tumor, malignant (128756002); Gastrointestinal stromal sarcoma (128756002); Gastrointestinal stromal sarcoma (420120006); Malignant GIST (gastrointestinal stromal tumor) (128756002)

Definition

A gastrointestinal stromal tumor that is characterized by large size (diameter greater than 10 cm for gastric localization and greater than 5 cm for intestinal localization) or more than 5 mitotic figures per 50 high power fields. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Gastrointestinal Stromal Tumor

Professional guidelines

PubMed

Giant malignant gastrointestinal stromal tumors: recurrence and effects of treatment with STI-571.
Chen TW, Liu HD, Shyu RY, Yu JC, Shih ML, Chang TM, Hsieh CB
World J Gastroenterol 2005 Jan 14;11(2):260-3. doi: 10.3748/wjg.v11.i2.260. PMID: 15633227Free PMC Article

Recent clinical studies

Etiology

Antiangiogenic drugs in oncology: a focus on drug safety and the elderly - a mini-review.
Boehm S, Rothermundt C, Hess D, Joerger M
Gerontology 2010;56(3):303-9. Epub 2009 Nov 26 doi: 10.1159/000262450. PMID: 19940466
The radiology of gastrointestinal stromal tumours (GIST).
King DM
Cancer Imaging 2005 Dec 15;5(1):150-6. doi: 10.1102/1470-7330.2005.0109. PMID: 16361144Free PMC Article
Giant malignant gastrointestinal stromal tumors: recurrence and effects of treatment with STI-571.
Chen TW, Liu HD, Shyu RY, Yu JC, Shih ML, Chang TM, Hsieh CB
World J Gastroenterol 2005 Jan 14;11(2):260-3. doi: 10.3748/wjg.v11.i2.260. PMID: 15633227Free PMC Article
Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells.
Insabato L, Di Vizio D, Ciancia G, Pettinato G, Tornillo L, Terracciano L
Arch Pathol Lab Med 2004 Apr;128(4):440-3. doi: 10.5858/2004-128-440-MGLAGS. PMID: 15043462
Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread.
Burkill GJ, Badran M, Al-Muderis O, Meirion Thomas J, Judson IR, Fisher C, Moskovic EC
Radiology 2003 Feb;226(2):527-32. doi: 10.1148/radiol.2262011880. PMID: 12563150

Diagnosis

Malignant gastrointestinal stromal tumor presenting with hemoperitoneum in puerperium: report of a case with review of the literature.
Varras M, Vlachakos N, Akrivis C, Vasilakaki T, Skafida E
World J Surg Oncol 2010 Nov 7;8:95. doi: 10.1186/1477-7819-8-95. PMID: 21054898Free PMC Article
The radiology of gastrointestinal stromal tumours (GIST).
King DM
Cancer Imaging 2005 Dec 15;5(1):150-6. doi: 10.1102/1470-7330.2005.0109. PMID: 16361144Free PMC Article
Giant malignant gastrointestinal stromal tumors: recurrence and effects of treatment with STI-571.
Chen TW, Liu HD, Shyu RY, Yu JC, Shih ML, Chang TM, Hsieh CB
World J Gastroenterol 2005 Jan 14;11(2):260-3. doi: 10.3748/wjg.v11.i2.260. PMID: 15633227Free PMC Article
Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells.
Insabato L, Di Vizio D, Ciancia G, Pettinato G, Tornillo L, Terracciano L
Arch Pathol Lab Med 2004 Apr;128(4):440-3. doi: 10.5858/2004-128-440-MGLAGS. PMID: 15043462
Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread.
Burkill GJ, Badran M, Al-Muderis O, Meirion Thomas J, Judson IR, Fisher C, Moskovic EC
Radiology 2003 Feb;226(2):527-32. doi: 10.1148/radiol.2262011880. PMID: 12563150

Therapy

Recurrence of gastric gastrointestinal stromal tumor 12 years after repeat hepatectomies for liver metastases: report of a case.
Fujinaga A, Ohta M, Masuda T, Itai Y, Nakanuma H, Kawasaki T, Kawano Y, Hirashita T, Endo Y, Inomata M
Clin J Gastroenterol 2021 Dec;14(6):1637-1641. Epub 2021 Sep 6 doi: 10.1007/s12328-021-01513-4. PMID: 34486081
Ten-Year Experience With Bowel Transplantation at Seoul St. Mary's Hospital.
Chang HK, Kim SY, Kim JI, Kim SI, Whang JK, Choi JY, Park JM, Jung ES, Rha SE, Kim DG, Moon IS, Lee MD
Transplant Proc 2016 Mar;48(2):473-8. doi: 10.1016/j.transproceed.2015.12.065. PMID: 27109981
Antiangiogenic drugs in oncology: a focus on drug safety and the elderly - a mini-review.
Boehm S, Rothermundt C, Hess D, Joerger M
Gerontology 2010;56(3):303-9. Epub 2009 Nov 26 doi: 10.1159/000262450. PMID: 19940466
The radiology of gastrointestinal stromal tumours (GIST).
King DM
Cancer Imaging 2005 Dec 15;5(1):150-6. doi: 10.1102/1470-7330.2005.0109. PMID: 16361144Free PMC Article
Giant malignant gastrointestinal stromal tumors: recurrence and effects of treatment with STI-571.
Chen TW, Liu HD, Shyu RY, Yu JC, Shih ML, Chang TM, Hsieh CB
World J Gastroenterol 2005 Jan 14;11(2):260-3. doi: 10.3748/wjg.v11.i2.260. PMID: 15633227Free PMC Article

Prognosis

Malignant gastrointestinal stromal tumor presenting with hemoperitoneum in puerperium: report of a case with review of the literature.
Varras M, Vlachakos N, Akrivis C, Vasilakaki T, Skafida E
World J Surg Oncol 2010 Nov 7;8:95. doi: 10.1186/1477-7819-8-95. PMID: 21054898Free PMC Article
Loss of chromosome 9p21 and decreased p16 expression correlate with malignant gastrointestinal stromal tumor.
Zhang Y, Cao H, Wang M, Zhao WY, Shen ZY, Shen DP, Ni XZ, Wu ZY, Shen YY, Song YY
World J Gastroenterol 2010 Oct 7;16(37):4716-24. doi: 10.3748/wjg.v16.i37.4716. PMID: 20872974Free PMC Article
The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000.
Tran T, Davila JA, El-Serag HB
Am J Gastroenterol 2005 Jan;100(1):162-8. doi: 10.1111/j.1572-0241.2005.40709.x. PMID: 15654796
Giant malignant gastrointestinal stromal tumors: recurrence and effects of treatment with STI-571.
Chen TW, Liu HD, Shyu RY, Yu JC, Shih ML, Chang TM, Hsieh CB
World J Gastroenterol 2005 Jan 14;11(2):260-3. doi: 10.3748/wjg.v11.i2.260. PMID: 15633227Free PMC Article
Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells.
Insabato L, Di Vizio D, Ciancia G, Pettinato G, Tornillo L, Terracciano L
Arch Pathol Lab Med 2004 Apr;128(4):440-3. doi: 10.5858/2004-128-440-MGLAGS. PMID: 15043462

Clinical prediction guides

Recurrence of gastric gastrointestinal stromal tumor 12 years after repeat hepatectomies for liver metastases: report of a case.
Fujinaga A, Ohta M, Masuda T, Itai Y, Nakanuma H, Kawasaki T, Kawano Y, Hirashita T, Endo Y, Inomata M
Clin J Gastroenterol 2021 Dec;14(6):1637-1641. Epub 2021 Sep 6 doi: 10.1007/s12328-021-01513-4. PMID: 34486081
ACRIN 6665/RTOG 0132 phase II trial of neoadjuvant imatinib mesylate for operable malignant gastrointestinal stromal tumor: monitoring with 18F-FDG PET and correlation with genotype and GLUT4 expression.
Van den Abbeele AD, Gatsonis C, de Vries DJ, Melenevsky Y, Szot-Barnes A, Yap JT, Godwin AK, Rink L, Huang M, Blevins M, Sicks J, Eisenberg B, Siegel BA
J Nucl Med 2012 Apr;53(4):567-74. Epub 2012 Mar 1 doi: 10.2967/jnumed.111.094425. PMID: 22381410Free PMC Article
Loss of chromosome 9p21 and decreased p16 expression correlate with malignant gastrointestinal stromal tumor.
Zhang Y, Cao H, Wang M, Zhao WY, Shen ZY, Shen DP, Ni XZ, Wu ZY, Shen YY, Song YY
World J Gastroenterol 2010 Oct 7;16(37):4716-24. doi: 10.3748/wjg.v16.i37.4716. PMID: 20872974Free PMC Article
Antiangiogenic drugs in oncology: a focus on drug safety and the elderly - a mini-review.
Boehm S, Rothermundt C, Hess D, Joerger M
Gerontology 2010;56(3):303-9. Epub 2009 Nov 26 doi: 10.1159/000262450. PMID: 19940466
The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000.
Tran T, Davila JA, El-Serag HB
Am J Gastroenterol 2005 Jan;100(1):162-8. doi: 10.1111/j.1572-0241.2005.40709.x. PMID: 15654796

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